5 Popular AdCC Treatments

AdCC or adenoid cystic carcinoma treatment is dependent on the extent and placing of the tumor, if it has metastasized and the general health condition of the person.

Below explicated are the widely employed treatments for adenoid cystic carcinoma, though patients are egged on to opt for participating in clinical trials when deciding on the line of treatment. Clinical trials are research studies performed for testing any new-fangled treatment for proving its safety quotient, efficacy and probably enhanced standard treatment.

1. Surgery

Surgical excision of the tumor is the line of treatment in case of AdCC, when carried out adhering to utmost safety standards and has likelihood of having a favourable result. A surgical oncologist is one proficient in cancer treatment performing the surgery. During surgical intervention, the tumor along with marginal tissues is taken out. In case the marginal tissues excised at the time of surgery contain no indication of malignancy in about two mm of the tissue adjoining the tumor, then it is an indicator of complete expurgation of the tumor and offers the optimal prospects of success in treating the location where the cancer originated.

As AdCC often has a tendency of spreading along the nerve branches, hence examination and establishing if nerves are affected is done by the doctor. A tumor that is considerably involving the nerves requires urgent removal.

The side effects associated with surgery differ dependent on the location of the surgery. Trepidations associated with all surgeries involving the parotid glands is that the nerves of the face could  be damaged or severed during surgery leading to facial drooping. Occasionally, grafting procedure of a facial nerve could be employed as a restorative means subsequent to surgery for the removal of the tumor. The degree of surgery being performed would differ by the tumor location and the inner structures that have been affected.

2. External-Beam Radiation Therapy

Radiation therapy employs high-power x-ray beams or other matter for obliterating malignant cells. The prevalent form of radiation therapy offered is known as external-beam radiation therapy administered from a device located outside the body. A specialist doctor (radiation oncologist) is the one who offers the treatment that is done generally as an adjuvant therapy (post-surgery therapy) for eradicating any infinitesimal remnant cancerous cells in the body following surgery.

Radiation therapy is generally not a pre-operative procedure in case of AdCC as several specialists believe that there is enhanced healing process of the operative wounds when radiation therapy is not offered before surgery.

3. IMRT or Intensity modulated radiation therapy

A particular process of eternal-beam radiation therapy called as IMRT or intensity modulated radiation therapy facilitates delivery of radiation therapy dosages of greater efficacy while sparing as much as normal cells as possible thus resulting in lesser side effects.

As radiation therapy is a target-specific treatment hence the side effects experienced would be dependent on what site the radiation therapy was offered. Usually when the treatment is performed on the head and neck regions, then side effects experienced could include soreness in the mouth or throat area, discomforting sensation and trouble during ingestion. The skin could show some form of reaction or burns that would be excruciating. Due to the outcome of radiation therapy on healthy tissues, particularly in the oral or throat area, such persons are persuaded to undergo prophylactic treatment prior to the radiation treatment commencing, conducted by a dental specialist who has received training in oncology.

Long-standing side effects faced due to radiation therapy differ in accordance to the locations that are part of the treatment. However, these could comprise of inadequate salivation leading to parched sensation in the mouth and deteriorating condition of the teeth. In few situations, a medicine for stimulating the parotid saliva gland and for increasing and restoring salivation is offered. Presently, amifostine or Ethyol – a medicine used for safeguarding the tissues at the time of radiation therapy is being researched. Scar formation or fibrosis (hardness or thickness) of the skin and muscles could arise for months or years following radiation therapy that could hinder lesions from being healed, rigidity in the neck and difficulty in ingestion. Other long-standing side effects which could arise comprise of hastened constriction of the carotid arteries that carry blood supply to the upper extremities of the body and could lead to hypothyroidism.

Entrants for radiation therapy are egged on to having a meeting with an experienced speech pathologist before undergoing the treatment, so that apt exercises could be carried out for maintaining potency and suppleness of the muscles linked with speech and ingestion.

4. Neutron and proton radiation therapy

Neutron therapy is diverse from radiation therapy and has a delivering capacity of twenty to hundred times greater energy in their course span leading to more annihilation of cancer cells in comparison to the traditionally employed radiation therapy. Neutron radiation therapy has been tried on several varying forms of tumors, and with those tumors inflicting the salivary glands especially AdCC appears to show the maximum benefits. In particular scenarios, neutron therapy could be the opted treatment in case of AdCC, especially in hard to reach places of the body where surgery could not be performed.  Nevertheless, neutron therapy holds more acute side effects in comparison to tradition radiation therapy, like acute soreness in the oral area and at times the throat and problems with ingestion, and hence is usually employed more frequently among individuals having ailments that could not be operated upon or disease that has relapsed. Medicines for facilitating salivation and protecting tissues could be offered in the course of the treatment. Neutrons could not be employed for the treatment of wide-spanning regions of the body in case of the disease having metastasized, however they could be utilised for treating disease spread which is one-off and leading to niggling symptoms like painful sensation, acting like blockages to part of the lung or exerting pressure on the spinal cord.

Proton radiation or proton beam therapy is a form of external-beam radiation therapy that employs protons instead of X-rays. During states of intense energy, protons have a capacity of destroying cancer cells. The benefits of proton therapy is the capability of better steering the manner of delivery of the radiation, thus immensely lowering the harm caused to the adjoining healthy tissues. But there is still dearth of extensive investigation in the usage of proton radiation therapy in case of AdCC.

Neutron or proton therapy is still not commonly obtainable and one has to speak to the doctor for enquiring about where such treatments are available.

5. Chemotherapy

Chemotherapy employs cancer-killing drugs offered by the medical oncologist. A typical chemotherapy schedule comprises of a particular set of cycles offered over a particular time span. Chemotherapy is usually not utilised in case of AdCC as this form of cancer seems to show lesser responsiveness to chemotherapy in comparison to other cancer forms. However, merging chemotherapy and radiation therapy is being explored for treating AdCC.

As AdCC is an atypical disease, and generally the presently obtainable chemotherapy has partial benefits, hence those having AdCC are recommended to participate in clinical trials for treating this condition.